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Selected Publications

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Relationships between sleep and addiction
Canellas F, de Lecea L.
Addicciones (2012)
[Abstract] [PDF]

Mechanism for Hypocretin-mediated sleep-to-wake transitions
Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea L.
Proc Natl Acad Sci USA (2012)
[Abstract] [PDF]

Hypocretins and the neurobiology of sleep-wake mechanisms
de Lecea L.
Prog Brain Res (2012)
[Abstract] [PDF]

Shining Light on Wakefulness and Arousal
de Lecea L, Carter ME, Adamantidis A
Biol Psychiatry (2012)
[Abstract] [PDF]

Activation of central orexin/hypocretin neurons by dietary amino acids
Karnani MM, Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L, Burdakov D
Neuron (2011)
[Abstract] [PDF]

Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin
Cordoba-Chacon J, Gahete MD, Pozo-Salas AI, Martinez-Fuentes AJ, de Lecea L, Gracia-Navarro F, Kineman RD, Castano JP, Luque RM
Endocrinology (2011)
[Abstract] [PDF]

Neural integration of reward, arousal, and feeding: Recruitment of VTA, lateral hypothalamus, and ventral striatal neurons
Gutierrez R, Lobo MK, Zhang F, de Lecea L
IUBMB Life (2011)
[Abstract] [PDF]

Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea
Sanchez-de-la-Torre M, Barcelo A, Pierola J, Esquinas C, de la Pena M, Duran-Cantolla J, Capote F, Masa JF, Marin JM, Vila M, Cao G, Martinez M, de Lecea L, Gozal D, Montserrat JM, Barbe F
Respir Med. (2011)
[Abstract] [PDF]

Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior
Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Tourino C, Bonci A, Deisseroth K, de Lecea L
J Neurosci. (2011)
[Abstract] [PDF]

Optogenetic disruption of sleep continuity impairs memory consolidation
Rolls A, Colas D, Adamantidis A, Carter M, Lanre-Amos T, Heller HC, de Lecea L
Proc Natl Acad Sci USA. (2011)
[Abstract] [PDF]

Optogenetic investigation of neural circuits in vivo
Carter ME, de Lecea L
Trends in Molecular Medicine (2011)
[In Press]

Sleep and metabolism: role of hypothalamic neuronal circuitry
Rolls A, Schaich Borg J, de Lecea L
Best Practice & Research. Clinical Endocrinology and Metabolism (2010) 24(5):817-28
[Abstract] [PDF]

Tuning arousal with optogenetic modulation of locus coeruleus neurons
Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L
Nature Neuroscience (2010) 13(12):1526-33
[Abstract] [PDF] [News & Views]

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R
Proceedings of the National Academy of Sciences (2010) 107(45):19567-72
[Abstract] [PDF]

Hypocretins in the control of sleep and wakefulness
Bonnavion P, de Lecea L
Current Neurology and Neuroscience Reports (2010) 10(3):174-9
[Abstract] [PDF]

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
Zhang F, Gradinaru V, Adamantidis A, Durand R, Airan RD, de Lecea L, Deisseroth K
Nature Protocols (2010) 5(3):439-56
[Abstract] [PDF]

Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior
Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F
Journal of Neuroscience (2010) 30(6):2300-10
[Abstract] [PDF]

Optogenetic deconstruction of sleep/wake circuitry in the brain
Adamantidis A, Carter ME, de Lecea L
Frontiers in Molecular Neuroscience (2010) 2:31
[Abstract] [PDF]

The role of hypocretin in driving arousal and goal-oriented behaviors
Boutrel B, Cannella N, de Lecea L
Brain Research (2010) 1314:103-11
[Abstract] [PDF]

A decade of hypocretins: past, present, and future of the neurobiology of arousal
de Lecea L
Acta Physiologica (2010) 198(3):203-8
[Abstract]
[PDF]

Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L
Journal of Neuroscience (2009) 29(35):10939-49
[Abstract] [PDF]

The hypocretins and their role in narcolepsy
Kroeger D, de Lecea L
CNS & Neurological Disorders Drug Targets (2009) 29(35):10939-49
[Abstract]

A role for Melanin-Concentrating Hormone in Learning and Memory
Adamantidis A, de Lecea L
Peptides (2009) 30(11):2066-70
[Abstract] [PDF]

Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K
Science (2009) 324(5930):1080-4
[Abstract] [PDF]

Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor 1 in mice
Paneda C, Huitron-Resendiz S, Frago LM, Chowen JA, Picetti R, de Lecea L, Roberts AJ
Journal of Neuroscience (2009) 29(13):4155-61
[Abstract] [PDF]

The brain hypocretins and their receptors: mediators of allostatic arousal
Carter ME, Schaich Borg J, de Lecea L
Current Opinion in Pharmacology (2009) 9(1):39-45
[Abstract] [PDF]

The hypocretins as sensors for metabolism and arousal
Adamantidis A, de Lecea L
Journal of Physiology (2009) 587(Pt 1):33-40
[Abstract] [PDF]

Sleep and metabolism: shared circuits, new connections
Adamantidis A, de Lecea L
Trends in Endocrinology and Metabolism (2008) 19(10):362-70
[Abstract] [PDF]

Neuropeptide interactions and REM sleep: a role for Urotensin II?
de Lecea L, Bourgin P
Peptides (2008) 29(5):845-51
[Abstract] [PDF]

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures
Qiu C, Zeyda T, Johnson B, Hochgeschwender U, de Lecea L, Tallent MK
Journal of Neuroscience (2008) 28(14):3567-76
[Abstract] [PDF]

Cortistatin--functions in the central nervous system
de Lecea L
Molecular and Cellular Endocrinology (2008) 286(1-2):88-95
[Abstract] [PDF]

Physiological arousal: a role for hypothalamic systems
Adamantidis A, de Lecea L
Cellular and Molecular Life Sciences (2008) 65(10):1475-88
[Abstract] [PDF]

Addiction and arousal: the hypocretin connection
Boutrel B, de Lecea L
Physiology & Behavior (2008) 93(4-5):947-51
[Abstract]

Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis A, Zhang F, Aravanis AM, Deisseroth K, de Lecea L
Nature (2007) 450(7168):420-4
[Abstract] [PDF]

Cortistatin promotes and negatively correlates with slow-wave sleep
Bourgin P, Fabre V, Huitron-Resendiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L
European Journal of Neuroscience (2007) 26(3):729-38
[Abstract]
[PDF]

Circuit breakers: optical technologies for probing neural signals and systems
Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth
Nature Reviews Neuroscience (2007) 8(8):577-81
[Abstract] [PDF]

Transgenic mice with a reduced core body temperature have an increased life span
Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Ressendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T
Science (2006) 314(5800):825-8
[Abstract] [PDF] [News & Views]

Addiction and arousal: alternative roles of hypothalamic peptides
de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R
Journal of Neuroscience (2006) 26(41):10372-5
[Abstract] [PDF]

Hypocretins: Integrators of Physiological Functions
de Lecea L, Sutcliffe JG (Eds.)
Springer (2005)
439 p. 158 illus., 34 in color., Hardcover, ISBN: 978-0-387-25000-7
[Link] [Cover]

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L
Proceedings of the National Academy of Sciences (2005) 102(52):19168-73
[Abstract] [PDF]

The hypocretins and sleep
de Lecea L, Sutcliffe JG
FEBS Journal (2005) 272(22):5675-88
[Abstract]
[PDF]

Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning
Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L
Molecular and Cellular Neuroscience (2005) 30(3):465-75
[Abstract] [PDF]

Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
Huitron-Resendiz S, Kristensen MP, Sanchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L
Journal of Neuroscience (2005) 25(23):5465-74
[Abstract] [PDF]

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L
Journal of Neuroscience (2004) 24(50):11439-48
[Abstract] [PDF]

Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain
Spier AD, Fabre V, de Lecea L
Regulatory Peptides (2004) 124(1-3):179-86
[Abstract] [PDF]

Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects
Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O
Neuron (2004) 43(4):487-97
[Abstract] [PDF] [News & Views]

Glutamatergic transmission in opiate and alcohol dependence
Siggins GR, Martin G, Roberto M, Nie Z, Madamba S, de Lecea L
Annals of the New York Academy of Sciences (2003) 1003:504-12
[Abstract] [PDF]

Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
de Lecea L, Sutcliffe JG, Fabre V
Neuropeptides (2002) 36(2-3):85-95
[Abstract] [PDF]

The hypocretins: setting the arousal threshold
Sutcliffe JG, de Lecea L
Nature Reviews Neuroscience (2002) 3(5):339-49
[Abstract] [PDF]

Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
Martin G, Fabre V, Siggins GR, de Lecea L
Regulatory Peptides (2002) 104(1-3):111-7
[Abstract] [PDF]

The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
de Lecea L, Sutcliffe JG
Cellular and Molecular Life Sciences (1999) 56(5-6):473-80
[Abstract] [PDF]

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
Bourgin P, Huitron-Resendiz S, Spier AD, Fabre V, Morte B, Criado J, Sutcliffe JG, Henriksen SJ, de Lecea L
Journal of Neuroscience (2000) 20(20):7760-5
[Abstract] [PDF]

The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
Sutcliffe JG, de Lecea L
Journal of Neuroscience Research (2000) 62(2):161-8
[Abstract] [PDF]

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions
Spier AD, de Lecea L
Brain Research. Brain Research Reviews (2000) 32(2-3):228-41
[Abstract] [PDF]

Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate
Calbet M, Guadano-Ferraz A, Spier AD, Maj M, Sutcliffe JG, Przewlocki R, de Lecea L
Brain Research. Molecular Brain Research (1999) 72(1):55-64
[Abstract] [PDF]

Structural and compositional determinants of cortistatin activity
Criado JR, Li H, Jiang X, Spina M, Huitron-Resendiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L.
Journal of Neuroscience Research (1999) 56(6):611-9
[Abstract] [PDF]

Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS
Journal of Neuroscience (1998) 18(23):9996-10015
[Abstract] [PDF]

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG
Proceedings of the National Academy of Sciences (1998) 95(1):322-7
[Abstract] [PDF]

Cortistatin is expressed in a distinct subset of cortical interneurons
de Lecea L, del Rio JA, Criado JR, Alcantara S, Morales M, Danielson PE, Henriksen SJ, Soriano E,
Sutcliffe JG
Journal of Neuroscience (1997) 17(15):5868-80
[Abstract] [PDF]

Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin
de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG
Genomics (1997) 42(3):499-506
[Abstract] [PDF]

Overview of the most prevalent hypothalmus-specific mRNAs, as identified by directional tag PCR subtraction
Gautvik KM, de Lecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG
Proceedings of the National Academy of Sciences (1996) 93(16):8733-8
[Abstract] [PDF]

A cortical neuropeptide with neuronal depressant and sleep-modulating properties
de Lecea L,Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG
Nature (1996) 381(6579):242-5
[Abstract] [PDF]