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Tuning arousal with optogenetic modulation of locus coeruleus neurons
Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L
Nature Neuroscience (2010) 13(12):1526-33
[Abstract] [PDF] [News & Views]

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R
Proceedings of the National Academy of Sciences (2010) 107(45):19567-72
[Abstract] [PDF]

Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior
Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F
Journal of Neuroscience (2010) 30(6):2300-10
[Abstract] [PDF]

Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L
Journal of Neuroscience (2009) 29(35):10939-49
[Abstract] [PDF]

Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K
Science (2009) 324(5930):1080-4
[Abstract] [PDF]

Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor 1 in mice
Paneda C, Huitron-Resendiz S, Frago LM, Chowen JA, Picetti R, de Lecea L, Roberts AJ
Journal of Neuroscience (2009) 29(13):4155-61
[Abstract] [PDF]

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures
Qiu C, Zeyda T, Johnson B, Hochgeschwender U, de Lecea L, Tallent MK
Journal of Neuroscience (2008) 28(14):3567-76
[Abstract] [PDF]

Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis A, Zhang F, Aravanis AM, Deisseroth K, de Lecea L
Nature (2007) 450(7168):420-4
[Abstract] [PDF]

Cortistatin promotes and negatively correlates with slow-wave sleep
Bourgin P, Fabre V, Huitron-Resendiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L
European Journal of Neuroscience (2007) 26(3):729-38
[Abstract]
[PDF]

Transgenic mice with a reduced core body temperature have an increased life span
Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Ressendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T
Science (2006) 314(5800):825-8
[Abstract] [PDF] [News & Views]

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L
Proceedings of the National Academy of Sciences (2005) 102(52):19168-73
[Abstract] [PDF]

Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning
Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L
Molecular and Cellular Neuroscience (2005) 30(3):465-75
[Abstract] [PDF]

Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons
Huitron-Resendiz S, Kristensen MP, Sanchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L
Journal of Neuroscience (2005) 25(23):5465-74
[Abstract] [PDF]

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L
Journal of Neuroscience (2004) 24(50):11439-48
[Abstract] [PDF]

Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain
Spier AD, Fabre V, de Lecea L
Regulatory Peptides (2004) 124(1-3):179-86
[Abstract] [PDF]

Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects
Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O
Neuron (2004) 43(4):487-97
[Abstract] [PDF] [News & Views]

Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
Martin G, Fabre V, Siggins GR, de Lecea L
Regulatory Peptides (2002) 104(1-3):111-7
[Abstract] [PDF]

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
Bourgin P, Huitron-Resendiz S, Spier AD, Fabre V, Morte B, Criado J, Sutcliffe JG, Henriksen SJ, de Lecea L
Journal of Neuroscience (2000) 20(20):7760-5
[Abstract] [PDF]

Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate
Calbet M, Guadano-Ferraz A, Spier AD, Maj M, Sutcliffe JG, Przewlocki R, de Lecea L
Brain Research. Molecular Brain Research (1999) 72(1):55-64
[Abstract] [PDF]

Structural and compositional determinants of cortistatin activity
Criado JR, Li H, Jiang X, Spina M, Huitron-Resendiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L.
Journal of Neuroscience Research (1999) 56(6):611-9
[Abstract] [PDF]

Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS
Journal of Neuroscience (1998) 18(23):9996-10015
[Abstract] [PDF]

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG
Proceedings of the National Academy of Sciences (1998) 95(1):322-7
[Abstract] [PDF]

Cortistatin is expressed in a distinct subset of cortical interneurons
de Lecea L, del Rio JA, Criado JR, Alcantara S, Morales M, Danielson PE, Henriksen SJ, Soriano E,
Sutcliffe JG
Journal of Neuroscience (1997) 17(15):5868-80
[Abstract] [PDF]

Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin
de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG
Genomics (1997) 42(3):499-506
[Abstract] [PDF]

Overview of the most prevalent hypothalmus-specific mRNAs, as identified by directional tag PCR subtraction
Gautvik KM, de Lecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG
Proceedings of the National Academy of Sciences (1996) 93(16):8733-8
[Abstract] [PDF]

A cortical neuropeptide with neuronal depressant and sleep-modulating properties
de Lecea L,Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG
Nature (1996) 381(6579):242-5
[Abstract] [PDF]