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Selected Publications

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Optogenetic investigation of neural circuits in vivo
Carter ME, de Lecea L
Trends in Molecular Medicine (2011)
[In Press]

Sleep and metabolism: role of hypothalamic neuronal circuitry
Rolls A, Schaich Borg J, de Lecea L
Best Practice & Research. Clinical Endocrinology and Metabolism (2010) 24(5):817-28
[Abstract] [PDF]

Hypocretins in the control of sleep and wakefulness
Bonnavion P, de Lecea L
Current Neurology and Neuroscience Reports (2010) 10(3):174-9
[Abstract] [PDF]

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
Zhang F, Gradinaru V, Adamantidis A, Durand R, Airan RD, de Lecea L, Deisseroth K
Nature Protocols (2010) 5(3):439-56
[Abstract] [PDF]

Optogenetic deconstruction of sleep/wake circuitry in the brain
Adamantidis A, Carter ME, de Lecea L
Frontiers in Molecular Neuroscience (2010) 2:31
[Abstract] [PDF]

The role of hypocretin in driving arousal and goal-oriented behaviors
Boutrel B, Cannella N, de Lecea L
Brain Research (2010) 1314:103-11
[Abstract] [PDF]

A decade of hypocretins: past, present, and future of the neurobiology of arousal
de Lecea L
Acta Physiologica (2010) 198(3):203-8
[Abstract]
[PDF]

The hypocretins and their role in narcolepsy
Kroeger D, de Lecea L
CNS & Neurological Disorders Drug Targets (2009) 29(35):10939-49
[Abstract]

A role for Melanin-Concentrating Hormone in Learning and Memory
Adamantidis A, de Lecea L
Peptides (2009) 30(11):2066-70
[Abstract] [PDF]

The brain hypocretins and their receptors: mediators of allostatic arousal
Carter ME, Schaich Borg J, de Lecea L
Current Opinion in Pharmacology (2009) 9(1):39-45
[Abstract] [PDF]

The hypocretins as sensors for metabolism and arousal
Adamantidis A, de Lecea L
Journal of Physiology (2009) 587(Pt 1):33-40
[Abstract] [PDF]

Sleep and metabolism: shared circuits, new connections
Adamantidis A, de Lecea L
Trends in Endocrinology and Metabolism (2008) 19(10):362-70
[Abstract] [PDF]

Neuropeptide interactions and REM sleep: a role for Urotensin II?
de Lecea L, Bourgin P
Peptides (2008) 29(5):845-51
[Abstract] [PDF]

Cortistatin--functions in the central nervous system
de Lecea L
Molecular and Cellular Endocrinology (2008) 286(1-2):88-95
[Abstract] [PDF]

Physiological arousal: a role for hypothalamic systems
Adamantidis A, de Lecea L
Cellular and Molecular Life Sciences (2008) 65(10):1475-88
[Abstract] [PDF]

Addiction and arousal: the hypocretin connection
Boutrel B, de Lecea L
Physiology & Behavior (2008) 93(4-5):947-51
[Abstract]

Circuit breakers: optical technologies for probing neural signals and systems
Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth
Nature Reviews Neuroscience (2007) 8(8):577-81
[Abstract] [PDF]

Addiction and arousal: alternative roles of hypothalamic peptides
de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R
Journal of Neuroscience (2006) 26(41):10372-5
[Abstract] [PDF]

Hypocretins: Integrators of Physiological Functions
de Lecea L, Sutcliffe JG (Eds.)
Springer (2005)
439 p. 158 illus., 34 in color., Hardcover, ISBN: 978-0-387-25000-7
[Link] [Cover]

The hypocretins and sleep
de Lecea L, Sutcliffe JG
FEBS Journal (2005) 272(22):5675-88
[Abstract]
[PDF]

Glutamatergic transmission in opiate and alcohol dependence
Siggins GR, Martin G, Roberto M, Nie Z, Madamba S, de Lecea L
Annals of the New York Academy of Sciences (2003) 1003:504-12
[Abstract] [PDF]

Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
de Lecea L, Sutcliffe JG, Fabre V
Neuropeptides (2002) 36(2-3):85-95
[Abstract] [PDF]

The hypocretins: setting the arousal threshold
Sutcliffe JG, de Lecea L
Nature Reviews Neuroscience (2002) 3(5):339-49
[Abstract] [PDF]

The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
de Lecea L, Sutcliffe JG
Cellular and Molecular Life Sciences (1999) 56(5-6):473-80
[Abstract] [PDF]

The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
Sutcliffe JG, de Lecea L
Journal of Neuroscience Research (2000) 62(2):161-8
[Abstract] [PDF]

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions
Spier AD, de Lecea L
Brain Research. Brain Research Reviews (2000) 32(2-3):228-41
[Abstract] [PDF]